منابع مشابه
Relieving oxidative stress in immune cells
1140 INSIGHTS | The Journal of Experimental Medicine Reticular dysgenesis (RD) is the most severe form of human severe combined immunodeficiency (SCID). It is associated with mutations in adenylate kinase 2 (AK2), the mitochondrial intermembrane space enzyme that regulates energy metabolism by reversibly catalyzing the reaction of ATP with AMP to generate two molecules of ADP. However, the impa...
متن کاملEfficacy of Ocimum sanctum for relieving stress: a preclinical study.
UNLABELLED HISTORY AND OBJECTIVE: The aim of this study was to study the anxiolytic effects of Ocimum sanctum stress-induced anxiety. MATERIALS AND METHODS The study was carried out using male albino rats (200 ± 50 gm), male albino mice (25 ± 100) the effect of O. sanctum evaluated for anxiety and depression using forced swim test FST and rotarod test. RESULTS Restraint stress (3 hours/day ...
متن کاملNaringin Reduces Hyperglycemia-Induced Cardiac Fibrosis by Relieving Oxidative Stress
INTRODUCTION Hyperglycemia promotes myocardial fibrotic lesions through upregulation of PKC and p38 in response to redox changes. The effects of naringin on hyperglycemia-induced myocardial fibrotic changes and its putative effects on PKC-β and p38 protein expression in type 1 rat model of diabetes are hereby investigated. METHODS Male Sprague-Dawley rats were divided into six groups I-VI. Gr...
متن کاملReleasing and Relieving Encounters
Lorant, T. 2002. Studies of Rejection in Experimental Xenotransplantation. Acta Universitatis Upsaliensis. Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1211. 60 pp. Uppsala. ISBN 91-554-5476-3. One main hurdle to xenotransplantation, i.e. transplantation between different species, is the immunological barrier that the organ meets in the recipient. The aim of thi...
متن کاملRelieving and Readjusting Pythagoras
Bill James invented the Pythagorean expectation in the late 70’s to predict a baseball team’s winning percentage knowing just their runs scored and allowed. His original formula estimates a winning percentage of RS/(RS+RA), where RS stands for runs scored and RA for runs allowed; later versions found better agreement with data by replacing the exponent 2 with numbers near 1.83. Miller and his c...
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ژورنال
عنوان ژورنال: Nature Chemical Biology
سال: 2019
ISSN: 1552-4450,1552-4469
DOI: 10.1038/s41589-019-0419-y